Complex Analysis of Retroposed Genes' Contribution to Human Genome, Proteome and Transcriptome.

ABSTRACT: Gene duplication is a major driver of organismal evolution. One of the main mechanisms of gene duplications is retroposition, a process in which mRNA is first transcribed into DNA and then reintegrated into the genome. Most gene retrocopies are depleted of the regulatory regions. Nevertheless, examples of functional retrogenes are rapidly increasing. These functions come from the gain of new spatio-temporal expression patterns, imposed by the content of the genomic sequence surrounding inserted cDNA and/or by selectively advantageous mutations, which may lead to the switch from protein coding to regulatory RNA. As recent studies have shown, these genes may lead to new protein domain formation through fusion with other genes, new regulatory RNAs or other regulatory elements. We utilized exi

SUBMITTER: Kubiak MR 

PROVIDER: S-EPMC7290577 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature