Effectiveness and safety of glucocorticoids to treat COVID-19: a rapid review and meta-analysis.

ABSTRACT:

Background

Glucocorticoids are widely used in the treatment of various pulmonary inflammatory diseases, but they are also often accompanied by significant adverse reactions. Published guidelines point out that low dose and short duration systemic glucocorticoid therapy may be considered for patients with rapidly progressing coronavirus disease 2019 (COVID-19) while the evidence is still limited.

Methods

We comprehensively searched electronic databases and supplemented the screening by conducting a manual search. We included randomized controlled trials (RCTs) and cohort studies evaluating the effectiveness and safety of glucocorticoids in children and adults with COVID-19, severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS), and conducted met

SUBMITTER: Lu S 

PROVIDER: S-EPMC7290628 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature