The protective effect of polyphyllin I on myocardial ischemia/reperfusion injury in rats.

ABSTRACT:

Background

Myocardial ischemia/reperfusion (I/R) injury has become a global public health concern. An increasing amount of evidence has shown that polyphyllin I (PPI) has anti-apoptotic and antioxidant functions. This study was performed to evaluate the cardioprotective effects of PPI in a rat model of myocardial I/R injury and the underlying mechanism.

Methods

We exposed induced a rat model of I/R injury by exposing rat hearts to left anterior descending coronary artery ligation for 30 min, followed by 24 h of reperfusion. Cardiac function was analyzed by echocardiography and HE staining. Myocardial apoptosis, inflammation, and oxidative stress were detected to analyze the PPI's role in I/R injury.

Results

The results showed that pretreatment with PPI improved impair

SUBMITTER: Huang R 

PROVIDER: S-EPMC7290651 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature