Inflammation-Induced Mucosal KYNU Expression Identifies Human Ileal Crohn's Disease.

ABSTRACT: The widely varying therapeutic response of patients with inflammatory bowel disease (IBD) continues to raise questions regarding the unclarified heterogeneity of pathological mechanisms promoting disease progression. While biomarkers for the differentiation of Crohn's disease (CD) versus ulcerative colitis (UC) have been suggested, specific markers for a CD subclassification in ileal CD versus colonic CD are still rare. Since an altered signature of the tryptophan metabolism is associated with chronic inflammatory disease, we sought to characterize potential biomarkers by focusing on the downstream enzymes and metabolites of kynurenine metabolism. Using immunohistochemical stainings, we analyzed and compared the mucosal tryptophan immune metabolism in bioptic samples from patients with act

SUBMITTER: Huhn M 

PROVIDER: S-EPMC7290775 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature