Nutraceutical Activity in Osteoarthritis Biology: A Focus on the Nutrigenomic Role.

ABSTRACT: Osteoarthritis (OA) is a disease associated to age or conditions that precipitate aging of articular cartilage, a post-mitotic tissue that remains functional until the failure of major homeostatic mechanisms. OA severely impacts the national health system costs and patients' quality of life because of pain and disability. It is a whole-joint disease sustained by inflammatory and oxidative signaling pathways and marked epigenetic changes responsible for catabolism of the cartilage extracellular matrix. OA usually progresses until its severity requires joint arthroplasty. To delay this progression and to improve symptoms, a wide range of naturally derived compounds have been proposed and are summarized in this review. Preclinical in vitro and in vivo studies have provided proof of principle

SUBMITTER: D'Adamo S 

PROVIDER: S-EPMC7291002 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature