Unmasking Intra-tumoral Heterogeneity and Clonal Evolution in NF1-MPNST.

ABSTRACT: Sarcomas are highly aggressive cancers that have a high propensity for metastasis, fail to respond to conventional therapies, and carry a poor 5-year survival rate. This is particularly true for patients with neurofibromatosis type 1 (NF1), in which 8%-13% of affected individuals will develop a malignant peripheral nerve sheath tumor (MPNST). Despite continued research, no effective therapies have emerged from recent clinical trials based on preclinical work. One explanation for these failures could be the lack of attention to intra-tumoral heterogeneity. Prior studies have relied on a single sample from these tumors, which may not be representative of all subclones present within the tumor. In the current study, samples were taken from three distinct areas within a single tumor from a pat

SUBMITTER: Moon CI 

PROVIDER: S-EPMC7291009 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature