HPV Infection Affects Human Sperm Functionality by Inhibition of Aquaporin-8.

ABSTRACT: Human sperm cells express different aquaporins (AQPs), AQP3, 7, 8, 11, which are localized both in the plasma membrane and in intracellular structures. Besides cell volume regulation and end stage of cytoplasm removal during sperm maturation, the role of AQPs extends also to reactive oxygen species (ROS) elimination. Moreover, oxidative stress has been shown to inhibit AQP-mediated H₂O₂ permeability. A decrease in AQPs functionality is related to a decrease in sperm cells number and motility. Here we investigate the possible effect of human Papillomavirus (HPV) on both expression and function of AQPs in human sperm cells of patients undergoing infertility couple evaluation. Stopped-flow light-scattering experiments demonstrated that HPV infection heavily reduced water

SUBMITTER: Pellavio G 

PROVIDER: S-EPMC7291193 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature