Pathway Analysis of Genes Identified through Post-GWAS to Underpin Prostate Cancer Aetiology.

ABSTRACT: Understanding the functional role of risk regions identified by genome-wide association studies (GWAS) has made considerable recent progress and is referred to as the post-GWAS era. Annotation of functional variants to the genes, including cis or trans and understanding their biological pathway/gene network enrichments, is expected to give rich dividends by elucidating the mechanisms underlying prostate cancer. To this aim, we compiled and analysed currently available post-GWAS data that is validated through further studies in prostate cancer, to investigate molecular biological pathways enriched for assigned functional genes. In total, about 100 canonical pathways were significantly, at false discovery rate (FDR)< 0.05), enriched in assigned genes using different algorithms.

SUBMITTER: Farashi S 

PROVIDER: S-EPMC7291227 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature