MicrobioLink: An Integrated Computational Pipeline to Infer Functional Effects of Microbiome-Host Interactions.

ABSTRACT: Microbiome-host interactions play significant roles in health and in various diseases including autoimmune disorders. Uncovering these inter-kingdom cross-talks propels our understanding of disease pathogenesis and provides useful leads on potential therapeutic targets. Despite the biological significance of microbe-host interactions, there is a big gap in understanding the downstream effects of these interactions on host processes. Computational methods are expected to fill this gap by generating, integrating, and prioritizing predictions-as experimental detection remains challenging due to feasibility issues. Here, we present MicrobioLink, a computational pipeline to integrate predicted interactions between microbial and host proteins together with host molecular networks. Using the conc

SUBMITTER: Andrighetti T 

PROVIDER: S-EPMC7291277 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature