Hybrid Biodegradable Nanomotors through Compartmentalized Synthesis.

ABSTRACT: Designer particles that are embued with nanomachinery for autonomous motion have great potential for biomedical applications; however, their development is highly demanding with respect to biodegradability/compatibility. Previously, biodegradable propulsive machinery based on enzymes has been presented. However, enzymes are highly susceptible to proteolysis and deactivation in biological milieu. Biodegradable hybrid nanomotors powered by catalytic inorganic nanoparticles provide a proteolytically stable alternative to those based upon enzymes. Herein we describe the assembly of hybrid biodegradable nanomotors capable of transducing chemical energy into motion. Such nanomotors are constructed through a process of compartmentalized synthesis of inorganic MnO₂ nanoparticles (MnPs)

SUBMITTER: Pijpers IAB 

PROVIDER: S-EPMC7291354 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature