Ontology highlight
ABSTRACT:
SUBMITTER: Haredi Abdelmonsef A
PROVIDER: S-EPMC7291371 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Haredi Abdelmonsef Aboubakr A Eldeeb Mohamed Mahmoud M El-Naggar Mohamed M Temairk Hussain H Mohamed Mosallam Ahmed A
Frontiers in molecular biosciences 20200605
The research explores the synthesis of a series of novel hybrid quinazolin-2,4-dione analogs bearing acetyl/amide bridged-nitrogen heterocyclic moieties such as azetidinone, pyrrole, oxazole, oxadiazole, thiazole, pyrazole, and thiazolidine scaffolds <b>2-16</b>. The newly synthesized compounds were structurally confirmed by means of IR, <sup>1</sup>H-NMR, <sup>13</sup>C-NMR, MS and elemental analysis. In addition, an <i>in silico</i> molecular docking analysis of new compounds and standard drug ...[more]