Ontology highlight
ABSTRACT:
SUBMITTER: Karki R
PROVIDER: S-EPMC7291389 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Karki Rajendra R Lee Ein E Sharma Bhesh R BR Banoth Balaji B Kanneganti Thirumala-Devi TD
Journal of immunology (Baltimore, Md. : 1950) 20200323 9
Inflammasomes are intracellular signaling complexes that are assembled in response to a variety of pathogenic or physiologic stimuli to initiate inflammatory responses. Ubiquitously present LPS in Gram-negative bacteria induces NLRP3 inflammasome activation that requires caspase-11. We have recently demonstrated that IFN regulatory factor (IRF) 8 was dispensable for caspase-11-mediated NLRP3 inflammasome activation during LPS transfection; however, its role in Gram-negative bacteria-mediated NLR ...[more]