Campylobacter bacteriophage DA10: an excised temperate bacteriophage targeted by CRISPR-cas.

ABSTRACT:

Background

Lytic bacteriophages that infect Campylobacter spp. have been utilized to develop therapeutic/decontamination techniques. However, the association of Campylobacter spp. and bacteriophages has been the focus of several strands of research aimed at understanding the complex relationships that have developed between predators and prey over evolutionary time. The activities of endogenous temperate bacteriophages have been used to evaluate genomic rearrangements and differential protein expression in host cells, and mechanisms of resistance to bacteriophage infection in campylobacters such as phase variation and CRISPR-mediated immunity.

Results

Temperate bacteriophage DA10 represents a novel excised and infective virus capable of replication in a restricted set of C.

SUBMITTER: Hooton S 

PROVIDER: S-EPMC7291426 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature