Plasma metabolites associated with arterial stiffness in patients with type 2 diabetes.

ABSTRACT:

Background

Although an increased arterial stiffness has been associated with traditional coronary risk factors, the risk factors and pathology of arterial stiffness remain unclear. In this study, we aimed to identify the plasma metabolites associated with arterial stiffness in patients with type 2 diabetes mellitus.

Methods

We used the metabolomic data of 209 patients with type 2 diabetes as the first dataset for screening. To form the second dataset for validation, we enlisted an additional 31 individuals with type 2 diabetes. The non-targeted metabolome analysis of fasting plasma samples using gas chromatography coupled with mass spectrometry and the measurement of brachial-ankle pulse wave velocity (baPWV) were performed.

Results

A total of 65 annotated metabolites

SUBMITTER: Katakami N 

PROVIDER: S-EPMC7291560 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature