Proteogenomic analysis of Inhibitor of Differentiation 4 (ID4) in basal-like breast cancer.

ABSTRACT:

Background

Basal-like breast cancer (BLBC) is a poorly characterised, heterogeneous disease. Patients are diagnosed with aggressive, high-grade tumours and often relapse with chemotherapy resistance. Detailed understanding of the molecular underpinnings of this disease is essential to the development of personalised therapeutic strategies. Inhibitor of differentiation 4 (ID4) is a helix-loop-helix transcriptional regulator required for mammary gland development. ID4 is overexpressed in a subset of BLBC patients, associating with a stem-like poor prognosis phenotype, and is necessary for the growth of cell line models of BLBC through unknown mechanisms.

Methods

Here, we have defined unique molecular insights into the function of ID4 in BLBC and the related disease high-grade

SUBMITTER: Baker LA 

PROVIDER: S-EPMC7291584 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature