Child maltreatment and cardiovascular disease: quantifying mediation pathways using UK Biobank.

ABSTRACT:

Background

Child maltreatment is associated with cardiovascular disease (CVD), but mediation pathways have not been fully elucidated. The aim of the current study was to determine and quantify the underlying pathways linking child maltreatment and CVD.

Methods

We conducted a retrospective cohort study using the UK Biobank. The number and types of child maltreatment, including abuse and neglect, were recalled by the participants. Lifestyle, biological, physical, and mental health factors measured at baseline were explored as potential mediators. Incident CVD was ascertained through record linkage after baseline measurement. Age, sex, ethnicity, area-based deprivation, and education level were adjusted for as confounders. Cox proportional hazard models were conducted to test f

SUBMITTER: Ho FK 

PROVIDER: S-EPMC7291652 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature