Environmental modifiers of RTS,S/AS01 malaria vaccine efficacy in Lilongwe, Malawi.

ABSTRACT:

Background

RTS,S/AS01 is the first vaccine against malaria to undergo pilot implementation, beginning in 2019 and vaccinating 360,000 children per year in Malawi, Ghana, and Kenya. The four-dose vaccine is given as a primary three-dose series with a fourth dose given approximately 18 months later. The efficacy of RTS,S/AS01 was variable among the 11 sites participating in the 2009-2014 phase III trial (MALARIA-055, NCT00866619), possibly due to differences in transmission intensity. However, a within-site examination of environmental factors related to transmission intensity and their impact on vaccine efficacy has yet to be conducted.

Methods

We implemented the phase III RTS,S/AS01 trial at the Malawi site, which enrolled 1578 infants (6-12 weeks) and children (5-17 months)

SUBMITTER: Bell GJ 

PROVIDER: S-EPMC7291743 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature