Epidemiology of Epstein-Barr virus infection and infectious mononucleosis in the United Kingdom.

ABSTRACT:

Background

Epstein-Barr Virus (EBV) is a ubiquitous gamma-herpesvirus with which ~ 95% of the healthy population is infected. EBV infection has been implicated in a range of haematological malignancies and autoimmune diseases. Delayed primary EBV infection increases the risk of subsequent complications. Contemporaneous seroepidemiological data is needed to establish best approaches for successful vaccination strategies in the future.

Methods

We conducted a sero-epidemiological survey using serum samples from 2325 individuals between 0 and 25 years old to assess prevalence of detectable anti-EBV antibodies. Second, we conducted a retrospective review of Hospital Episode Statistics to examine changes in Infectious Mononucleosis (IM) incidence over time. We then conducted a lar

SUBMITTER: Kuri A 

PROVIDER: S-EPMC7291753 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature