Susceptibility of male wild type mouse strains to antipsychotic-induced weight gain.

ABSTRACT: While both men and women gain weight as a side effect of antipsychotic (AP) treatment, studies in mice have found only female mice are susceptible to weight gain. Therefore, to we set out to identify a strain of male mice that gain significant weight in response to APs which could better model AP-induced weight gain observed in humans. These studies determined that male Balb/c mice developed late onset olanzapine-induced weight gain. Patients often take APs for many years and thus understanding AP-mediated changes in food intake, energy expenditure and body weight regulation is particularly important.

SUBMITTER: Zapata RC 

PROVIDER: S-EPMC7291782 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature