Emerging antisense oligonucleotide and viral therapies for amyotrophic lateral sclerosis.

ABSTRACT:

Purpose of review

Amyotrophic lateral sclerosis (ALS) is a rapidly fatal disease for which there is currently no effective therapy. The present review describes the current progress of existing molecular therapies in the clinical trial pipeline and highlights promising future antisense oligonucleotide (ASO) and viral therapeutic strategies for treating ALS.

Recent findings

The immense progress in the design of clinical trials and generation of ASO therapies directed towards superoxide dismutase-1 (SOD1) and chromosome 9 open reading frame 72 (C9orf72) repeat expansion related disease have been propelled by fundamental work to identify the genetic underpinnings of familial ALS and develop relevant disease models. Preclinical studies have also identified promising targets for

SUBMITTER: Ly CV 

PROVIDER: S-EPMC7291817 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature