Retinal innervation tunes circuits that drive nonphotic entrainment to food.

ABSTRACT: Daily changes in light and food availability are major time cues that influence circadian timing¹. However, little is known about the circuits that integrate these time cues to drive a coherent circadian output^1-3. Here we investigate whether retinal inputs modulate entrainment to nonphotic cues such as time-restricted feeding. Photic information is relayed to the suprachiasmatic nucleus (SCN)-the central circadian pacemaker-and the intergeniculate leaflet (IGL) through intrinsically photosensitive retinal ganglion cells (ipRGCs)⁴. We show that adult mice that lack ipRGCs from the early postnatal stages have impaired entrainment to time-restricted feeding, whereas ablation of ipRGCs at later stages had no effect. Innervation of ipRGCs at early postnatal sta

SUBMITTER: Fernandez DC 

PROVIDER: S-EPMC7291822 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature