Three-Dimensional GRE T_1ρ mapping of the brain using tailored variable flip-angle scheduling.

ABSTRACT:

Purpose

To introduce a new approach called tailored variable flip-angle (VFA) scheduling for SNR-efficient 3D T_1ρ mapping of the brain using a magnetization-prepared gradient-echo sequence.

Methods

Simulations were used to assess the relative SNR efficiency, quantitative accuracy, and spatial blurring of tailored VFA scheduling for T_1ρ mapping of brain tissue compared with magnetization-prepared angle-modulated partitioned k-space spoiled gradient-echo snapshots (MAPSS), a state-of-the-art technique for accurate 3D gradient-echo T_1ρ mapping. Simulations were also used to calculate optimal imaging parameters for tailored VFA scheduling versus MAPSS, without and with nulling of CSF. Four participants were imaged at 3T MRI to demonstrate the fea

SUBMITTER: Johnson CP 

PROVIDER: S-EPMC7291845 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature