Canine prostatic cancer cell line (LuMa) with osteoblastic bone metastasis.

ABSTRACT:

Background

Osteoblastic bone metastasis represents the most common complication in men with prostate cancer (PCa). During progression and bone metastasis, PCa cells acquire properties similar to bone cells in a phenomenon called osteomimicry, which promotes their ability to metastasize, proliferate, and survive in the bone microenvironment. The mechanism of osteomimicry resulting in osteoblastic bone metastasis is unclear.

Methods

We developed and characterized a novel canine prostatic cancer cell line (LuMa) that will be useful to investigate the relationship between osteoblastic bone metastasis and osteomimicry in PCa. The LuMa cell line was established from a primary prostate carcinoma of a 13-year old mixed breed castrated male dog. Cell proliferation and gene expression

SUBMITTER: Elshafae SM 

PROVIDER: S-EPMC7291846 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature