Targeted Stimulation of Human Orbitofrontal Networks Disrupts Outcome-Guided Behavior.

ABSTRACT: Outcome-guided behavior requires knowledge about the current value of expected outcomes. Such behavior can be isolated in the reinforcer devaluation task, which assesses the ability to infer the current value of specific rewards after devaluation. Animal lesion studies demonstrate that orbitofrontal cortex (OFC) is necessary for normal behavior in this task, but a causal role for human OFC in outcome-guided behavior has not been established. Here, we used sham-controlled, non-invasive, continuous theta-burst stimulation (cTBS) to temporarily disrupt human OFC network activity by stimulating a site in the lateral prefrontal cortex that is strongly connected to OFC prior to devaluation of food odor rewards. Subjects in the sham group appropriately avoided Pavlovian cues associated with deval

SUBMITTER: Howard JD 

PROVIDER: S-EPMC7291849 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature