Heterogeneity of adult masseter muscle satellite cells with cardiomyocyte differentiation potential.

ABSTRACT: Although resident cardiac stem cells have been reported, regeneration of functional cardiomyocytes (CMs) remains a challenge. The present study identifies an alternative progenitor source for CM regeneration without the need for genetic manipulation or invasive heart biopsy procedures. Unlike limb skeletal muscles, masseter muscles (MM) in the mouse head are developed from Nkx2-5 mesodermal progenitors. Adult masseter muscle satellite cells (MMSCs) display heterogeneity in developmental origin and cell phenotypes. The heterogeneous MMSCs that can be characterized by cell sorting based on stem cell antigen-1 (Sca1) show different lineage potential. While cardiogenic potential is preserved in Sca1⁺ MMSCs as shown by expression of cardiac progenitor genes (including Nkx2-5), skelet

SUBMITTER: Huang W 

PROVIDER: S-EPMC7291879 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature