IL-12 Signaling Contributes to the Reprogramming of Neonatal CD8⁺ T Cells.

ABSTRACT: Neonates are highly susceptible to intracellular pathogens, leading to high morbidity and mortality rates. CD8⁺ T lymphocytes are responsible for the elimination of infected cells. Understanding the response of these cells to normal and high stimulatory conditions is important to propose better treatments and vaccine formulations for neonates. We have previously shown that human neonatal CD8⁺ T cells overexpress innate inflammatory genes and have a low expression of cytotoxic and cell signaling genes. To investigate the activation potential of these cells, we evaluated the transcriptome of human neonatal and adult naïve CD8⁺ T cells after TCR/CD28 signals ± IL-12. We found that in neonatal cells, IL-12 signals contribute to the adult-like expression of gene

SUBMITTER: Gutierrez-Reyna DY 

PROVIDER: S-EPMC7292210 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature