Sound frequency dependence of duration mismatch negativity recorded from awake rats.

ABSTRACT:

Aims

The brain function that detects deviations in the acoustic environment can be evaluated with mismatch negativity (MMN). MMN to sound duration deviance has recently drawn attention as a biomarker for schizophrenia. Nonhuman animals, including rats, also exhibit MMN-like potentials. Therefore, MMN research in nonhuman animals can help to clarify the neural mechanisms underlying MMN production. However, results from preclinical MMN studies on duration deviance have been conflicting. We investigated the effect of sound frequency on MMN-like potentials to duration deviance in rats.

Methods

Event-related potentials were recorded from an electrode placed on the primary auditory cortex of free-moving rats using an oddball paradigm consisting of 50-ms duration tones (standards)

SUBMITTER: Inaba H 

PROVIDER: S-EPMC7292213 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature