Social defeat stress induces phosphorylation of extracellular signal-regulated kinase in the leptomeninges in mice.

ABSTRACT:

Aims

Animal studies using various stress models have shown that excessive environmental stress induces depression? and anxiety?like behaviors through inflammatory responses in the brain and periphery. Although the leptomeningeal cells have multiple functions related to inflammatory responses in the brain, whether environmental stress influences the leptomeninges remains unknown. In this study, we aimed to examine phosphorylation of the extracellular signal-regulated kinase (ERK) in the leptomeninges.

Methods

We subjected C57BL/6 male mice to a single episode of social defeat stress and analyzed the expression of phosphorylated ERK in the leptomeninges by immunohistochemistry.

Results

Social defeat stress in mice induced phosphorylation of ERK in the leptomeninges, adj

SUBMITTER: Okamura S 

PROVIDER: S-EPMC7292265 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature