Synapse-selective rapid potentiation of hippocampal synaptic transmission by 7,8-dihydroxyflavone.

ABSTRACT:

Aim

The identification of 7,8-dihydroxyflavone (DHF) as a small molecule agonist for tropomyosin-related kinase B (TrkB) facilitated understanding of the role of TrkB signaling in regulating higher brain functions. DHF can penetrate the blood-brain barrier after systemic administration and changes the performance of cognitive and emotional behavioral tasks. However, it is poorly understood how DHF modulates neuronal functions at cellular levels. Aiming to understand the cellular basis underlying DHF-induced modifications of the brain functions, we examined the effects of DHF on the hippocampal excitatory synaptic transmission.

Methods

Field excitatory postsynaptic potentials were recorded using hippocampal slices prepared from adult male mice. Effects of bath-applied DHF on

SUBMITTER: Kobayashi K 

PROVIDER: S-EPMC7292275 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature