Hypothalamic-pituitary-adrenal axis differentially responses to morning and evening psychological stress in healthy subjects.

ABSTRACT:

Aim

The hypothalamic-pituitary-adrenal (HPA) axis responds to changing environmental demands including psychological stressors. The aim of the present study was to assess whether the time of day effects on the acute response of HPA axis activity to acute psychological stress.

Method

We studied 27 healthy young subjects. The subjects were participated two experiments as follows. In the first experiment, subjects were instructed to keep their regular sleep schedule for 2 weeks which were measured by using a wrist-worn activity monitor. Afterward, to evaluate a diurnal rhythm of salivary cortisol, eight saliva samples were collected during waking period every 2 hours from when the subjects woke up. In the second experiment, the subjects were randomly assigned to two groups. The

SUBMITTER: Yamanaka Y 

PROVIDER: S-EPMC7292277 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature