Antidepressant amitriptyline-induced matrix metalloproteinase-9 activation is mediated by Src family tyrosine kinase, which leads to glial cell line-derived neurotrophic factor mRNA expression in rat astroglial cells.

ABSTRACT:

Background

Astrocytes have been implicated in the pathophysiology of mood disorders and in the mechanism of the pharmacological effects of antidepressant drugs by the production of neurotrophic/growth factors. Previous studies have identified astrocyte-expressed Gα_i/o -coupled lysophosphatidic acid receptor 1 (LPAR1), as being involved in antidepressant-induced production of glial cell line-derived neurotrophic factor (GDNF) and matrix metalloproteinase-9 (MMP-9) activation, an important step in the production of GNDF. However, the precise mechanism of MMP-9 activation by antidepressants has yet to be identified, in particular the intracellular signaling pathway between LPAR1/Gα_i/o and MMP-9.

Methods and results

Treatment of rat C6 astroglial cells (C6

SUBMITTER: Abe H 

PROVIDER: S-EPMC7292280 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature