Roles of noradrenergic transmission within the ventral part of the bed nucleus of the stria terminalis in bidirectional brain-intestine interactions.

ABSTRACT:

Aims

The bed nucleus of the stria terminalis (BNST) is a limbic structure mediating autonomic and neuroendocrine responses and negative affective states such as anxiety and fear. We previously demonstrated that noradrenergic transmission via β-adrenoceptors within the ventral part of BNST (vBNST) is involved in bidirectional interactions between the brain and the upper gastrointestinal (GI) tract. The present study aimed to examine the roles of intra-vBNST noradrenergic transmission via β-adrenoceptors in bidirectional interactions between the brain and lower GI tract.

Methods

In vivo microdialysis experiments were performed to examine colorectal distention (CRD)-induced noradrenaline release within the vBNST of freely moving male Sprague-Dawley rats. Colonic transit and abd

SUBMITTER: Ide S 

PROVIDER: S-EPMC7292287 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature