Comparative analysis of palmitoylation sites of serotonin (5-HT) receptors in vertebrates.

ABSTRACT:

Background

In the vertebrate central nervous system as well as in the periphery, serotonin, also known as 5-hydroxytriptamine (5-HT), function as a neurotransmitter, a hormone or a mitogen. 5-HT receptors are composed of 7 family 5-HT_1-7 receptors, comprising of 14 structurally and pharmacologically distinct 5-HT receptor subtypes. Previous experimental studies showed that mouse 5-HT_1A , 5-HT₄ and 5-HT₇ receptors are regulated by post-translational protein palmitoylation, the reversible attachment of the lipid palmitate to intracellular cysteine residues. Here, we further focused on conservation of these putative palmitoylation sites found in vertebrate 5-HT receptor orthologs.

Methods and results

Analysis of sequence databases pro

SUBMITTER: Kaizuka T 

PROVIDER: S-EPMC7292288 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature