Behavioral effects of long-term oral administration of aluminum ammonium sulfate in male and female C57BL/6J mice.

ABSTRACT:

Background

Aluminum (Al) is considered to be a neurotoxic metal, and excessive exposure to Al has been reported to be a potential risk factor for neurodegenerative diseases. Al ammonium sulfate is one of the Al compounds that is widely used as a food additive. However, the effects of the oral administration of Al ammonium sulfate on physical development and behavior remain to be examined.

Methods

In this study, we investigated the effects of the administration of Al ammonium sulfate 12-water dissolved in drinking water (0.075 mg/mL) beginning in adolescence on various types of behavior in adult female C57BL/6J mice through a battery of behavioral tests (low-dose experiment; Experiment 1). We further examined the behavioral effects of the oral administration of a higher dose

SUBMITTER: Shoji H 

PROVIDER: S-EPMC7292291 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature