Bidirectional brain-gut interactions: Involvement of noradrenergic transmission within the ventral part of the bed nucleus of the stria terminalis.

ABSTRACT:

Introduction

Although the important roles of bidirectional interactions between the brain and gut in stress and emotional responses have long been recognized, the underlying neuronal mechanisms remain unclear. The bed nucleus of the stria terminalis (BNST) is a limbic structure involved in stress responses and negative affective states, such as anxiety and depression. We have previously demonstrated that noradrenergic transmission within the ventral part of the BNST (vBNST) plays a crucial role in anxiety-like behaviors and pain-induced aversion.

Objectives

This study aimed to examine the involvement of noradrenergic transmission via β-adrenoceptors within the vBNST in bidirectional brain-gut interactions.

Methods

We measured the gastric distention (GD)-induced noradr

SUBMITTER: Ide S 

PROVIDER: S-EPMC7292304 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature