Transcriptomic evidence for immaturity induced by antidepressant fluoxetine in the hippocampus and prefrontal cortex.

ABSTRACT:

Aims

The molecular and cellular mechanisms underlying the antidepressant effects of fluoxetine in the brain are not fully understood. Emerging evidence has led to the hypothesis that chronic fluoxetine treatment induces dematuration of certain types of mature neurons in rodents. These studies have focused on the properties of typical molecular and/or electrophysiological markers for neuronal maturation. Nevertheless, it remains unknown whether dematuration-related phenomena are present at the genome-wide gene expression level.

Methods

Based on the aforementioned hypothesis, we directly compared transcriptome data between fluoxetine-treated adult mice and those of naive infants in the hippocampus and medial prefrontal cortex (mPFC) to assess similarities and/or differences. W

SUBMITTER: Hagihara H 

PROVIDER: S-EPMC7292305 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature