Repeated methamphetamine treatment increases spine density in the nucleus accumbens of serotonin transporter knockout mice.

ABSTRACT: Aim: Repeated psychostimulant drug treatment, including methamphetamine, in rodents readily produces behavioral sensitization, which reflects altered brain function caused by repeated drug exposure. Dendritic remodeling of medium spiny neurons in the nucleus accumbens is thought to be an essential mechanism underlying behavioral sensitization. We recently showed that chronic methamphetamine treatment did not produce behavioral sensitization in serotonin transporter knockout mice.

Methods: In this study, we report the spine density of medium spiny neurons in the nucleus accumbens after repeated methamphetamine injection to examine morphological alterations in serotonin transporter knockout mice.

Results: Golgi-COX staining clearly showed that the spine den

SUBMITTER: Kasahara Y 

PROVIDER: S-EPMC7292310 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature