A randomized controlled study of the effect of ifenprodil on alcohol use in patients with alcohol dependence.

ABSTRACT:

Aim

This prospective, randomized, controlled, rater-blinded study investigated the effect of G protein-activated inwardly rectifying potassium (GIRK) channel inhibitor ifenprodil on alcohol use in patients with alcohol dependence.

Methods

The participants were 68 outpatients with alcohol dependence who were assigned to an ifenprodil group (administered 60 mg ifenprodil per day for 3 months) or control group (administered 600 mg ascorbic acid and calcium pantothenate per day for 3 months). The participants completed a questionnaire that included the frequency of alcohol drinking and presence of heavy drinking before the study period (time 1) and 3 months after the start of the study period (time 2). The alcohol use score was calculated using these two items.

Results

Va

SUBMITTER: Sugaya N 

PROVIDER: S-EPMC7292313 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature