GABAergic function in the lateral hypothalamus regulates feeding behavior: Possible mediation via orexin.

ABSTRACT: Aim: The lateral hypothalamus (LH) is known as the hunger center, but the mechanisms through which the LH regulates food intake are unclear. Since GABA neurons are reported to project to the LH, the present study investigated the role of GABAergic function in the LH in the regulation of feeding behavior.

Methods: GABA levels in the LH were measured by in vivo microdialysis. Food intake after drug injection into the LH was measured every 1 hour for 4 hours. The mRNA levels were measured using RT-PCR.

Results: Food intake significantly increased GABA levels in the LH, suggesting that food intake stimulates GABAergic function in the LH. Injection of the GABA_A receptor agonist muscimol into the LH significantly inhibited food intake, whereas inject

SUBMITTER: Yonemochi N 

PROVIDER: S-EPMC7292314 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature