Chemokine CXCL1 is responsible for cocaine-induced reward in mice.

ABSTRACT:

Aim

We have previously demonstrated that upregulation of CC chemokines through dopamine receptor signaling in the prefrontal cortex (PFC) underlies methamphetamine (Meth)-induced reward. Given the common pharmacological property of Meth and cocaine (Coca), which are highly addictive psychostimulants, we hypothesized that chemokines may also contribute to Coca-induced reward. The aim of this study was to identify a key chemokine-mediating Coca-induced reward in mice.

Methods

The mRNA expression levels of chemokines were measured by reverse transcription-quantitative polymerase chain reaction. Coca-induced reward was evaluated by conditioned place preference test.

Results

We found that mRNA expression levels of CC chemokine ligand 2 (CCL2), CCL7, and CXC chemokine ligan

SUBMITTER: Saika F 

PROVIDER: S-EPMC7292320 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature