Comprehensive behavioral analysis of heterozygous Syngap1 knockout mice.

ABSTRACT:

Aims

Synaptic Ras GTPase-activating protein 1 (SYNGAP1) regulates synaptic plasticity through AMPA receptor trafficking. SYNGAP1 mutations have been found in human patients with intellectual disability (ID) and autism spectrum disorder (ASD). Almost every individual with SYNGAP1-related ID develops epilepsy, and approximately 50% have ASD. SYNGAP1-related ID is estimated to account for at least 1% of ID cases. In mouse models with Syngap1 mutations, strong cognitive and affective dysfunctions have been reported, yet some findings are inconsistent across studies. To further understand the behavioral significance of the SYNGAP1 gene, we assessed various domains of behavior in Syngap1 heterozygous mutant mice using a behavioral test battery.

Methods

Male mice with a heterozygou

SUBMITTER: Nakajima R 

PROVIDER: S-EPMC7292322 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature