Bee honey protects astrocytes against oxidative stress: A preliminary in vitro investigation.

ABSTRACT:

Aim

Bee honey is widely used as a bioactive food to improve general health and produce therapeutic benefits in various physical disorders. It also improves cognitive and mood-related behaviors and symptoms in mice and humans. Still, its direct effect on brain cells is unclear. Here, we examined the effect of whole honey on the survival of astrocytes exposed to oxidative stress.

Methods

Cultured cortical astrocytes were treated with honey (0.1%, 0.3%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 3%, and 5% [v/v]) for 24 hours followed by H₂ O₂ (100 μmol/L) for 3 hours. Cellular viability was assessed with MTT assay.

Results

Honey prevented cellular death in a dose-dependent manner compared with H₂ O_2- treated cells. Honey at 1% concentr

SUBMITTER: Ali AM 

PROVIDER: S-EPMC7292328 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature