Study of 45 candidate genes suggests CACNG2 may be associated with lithium response in bipolar disorder.

ABSTRACT:

Background

Bipolar disorder is a neuropsychiatric disorder that is characterized by fluctuations between manic and depressive phases. Lithium is the original and best mood stabilizing treatment for bipolar disorder. While its mechanism is not well understood, it is believed to have a strong genetic component, as several studies suggest that lithium responsiveness, in bipolar disorder, is heritable. In this study we aimed to identify genetic variants that are associated with lithium responsiveness in bipolar disorder.

Methods

Here we present two cohorts; a retrospective cohort in which patients were surveyed about their response to lithium, and a prospective cohort, in which patients were placed on a lithium monotherapy and monitored for their response to lithium. In both coh

SUBMITTER: Miranda A 

PROVIDER: S-EPMC7292366 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature