Decreased Sox2 Messenger RNA Expression in Basal Cell Carcinoma.

ABSTRACT:

Background

Sox2, zeb1, and p21 have been implicated in aggressive behavior of squamous cell carcinoma (SCC) and melanoma. However, their expression level in basal cell carcinoma (BCC) has not been elucidated. We hypothesized BCC, contrary to SCC, and melanoma, could be a suitable model to study mechanisms which attenuate tumor metastasis. The aim of this study was to examine the messenger RNA (mRNA) expression levels of sox2, zeb1, and p21 in BCC.

Materials and methods

Twenty-seven nonmetastatic BCC and twelve normal skin samples were evaluated using real-time reverse transcriptase polymerase chain reaction.

Results

The stemness marker sox2 demonstrated marked down-regulation, but zeb1 and p21 showed no si

SUBMITTER: Ahmadi-Beni R 

PROVIDER: S-EPMC7292465 | biostudies-literature | 2020 May-Jun

REPOSITORIES: biostudies-literature