Polymeric nanofibrous scaffolds laden with cell-derived extracellular matrix for bone regeneration.

ABSTRACT: Bone tissue engineering aims to alleviate the shortage of available autograft material and the biological/mechanical incompatibility of allografts through fabrication of bioactive synthetic bone graft substitutes. However, these substitute grafting materials have insufficient biological potency that limits their clinical efficacy in regenerating large defects. Extracellular matrix, a natural tissue scaffold laden with biochemical and structural cues regulating cell adhesion and tissue morphogenesis, may be a versatile supplement that can extend its biological functionality to synthetic grafts. Embedding decellularized extracellular matrix (dECM) into synthetic polymers offers a promising strategy to enhance cellular response to synthetic materials, mitigate physical and mechanical limitati

SUBMITTER: Junka R 

PROVIDER: S-EPMC7292471 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature