Increased risk of thrombotic events in cold agglutinin disease: A 10-year retrospective analysis.

ABSTRACT:

Background

Cold agglutinin disease (CAD) is a rare autoimmune hemolytic anemia mediated by IgM autoantibodies that trigger hemolysis via classical complement pathway. Increased incidence of thrombotic events (TEs) has been reported in patients with other forms of hemolysis. The incidence of TEs in patients with CAD is unknown.

Objective

Evaluate TE risk in patients with CAD.

Patients/methods

This is a matched cohort comparison study evaluating the risk of TEs in patients with CAD and without CAD over a 10-year period. A total of 608 patients with CAD were identified in the Optum Claims-Clinical data set by reviewing clinical notes for CAD terms and matched with up to 10 patients without CAD (N = 5873). TEs were defined as the first medical claim for a TE using Interna

SUBMITTER: Broome CM 

PROVIDER: S-EPMC7292660 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature