Is the time in therapeutic range on coumarins predicted by previous time in therapeutic range?

ABSTRACT:

Background

The benefit of vitamin K antagonists depends on the time within the therapeutic range (TTR). A patient's previous TTR could be a factor in the decision to change the anticoagulation regimen. However, the predictive value of a previous TTR for a future TTR is not well established, nor is it clear which TTR should prompt action.

Objectives

To investigate the predictive performance of a TTR and identify a threshold below which no recovery of TTR should be expected.

Patients/methods

From 18 031 patients who used acenocoumarol in a first-line anticoagulation clinic, a TTR was calculated over multiple periods of 90, 180, and 365 days each. We assessed the correlation between baseline and later TTR and the separation between groups by quintile of baseline TTR. We

SUBMITTER: van Miert JHA 

PROVIDER: S-EPMC7292664 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature