Functionally distinct subgroups of oligodendrocyte precursor cells integrate neural activity and execute myelin formation.

ABSTRACT: Recent reports have revealed that oligodendrocyte precursor cells (OPCs) are heterogeneous. It remains unclear whether such heterogeneity reflects different subtypes of cells with distinct functions or instead reflects transiently acquired states of cells with the same function. By integrating lineage formation of individual OPC clones, single-cell transcriptomics, calcium imaging and neural activity manipulation, we show that OPCs in the zebrafish spinal cord can be divided into two functionally distinct groups. One subgroup forms elaborate networks of processes and exhibits a high degree of calcium signaling, but infrequently differentiates despite contact with permissive axons. Instead, these OPCs divide in an activity- and calcium-dependent manner to produce another subgroup, with high

SUBMITTER: Marisca R 

PROVIDER: S-EPMC7292734 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature