Trajectories of childhood anxiety disorders in two generations at high risk.

ABSTRACT:

Background

The course of anxiety disorders during childhood is heterogeneous. In two generations at high or low risk, we described the course of childhood anxiety disorders and evaluated whether parent or grandparent major depressive disorder (MDD) predicted a persistent anxiety course.

Methods

We utilized a multigenerational study (1982-2015), following children (second generation, G2) and grandchildren (third generation, G3) of generation 1 (G1) with either moderate/severe MDD or no psychiatric illness. Psychiatric diagnoses were based on diagnostic interviews. Using group-based trajectory models, we identified clusters of children with similar anxiety disorder trajectories (age 0-17).

Results

We identified three primary trajectories in G2 (N = 275) and G3 (N = 118)

SUBMITTER: Bushnell GA 

PROVIDER: S-EPMC7292740 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature