Dynamic tractography: Integrating cortico-cortical evoked potentials and diffusion imaging.

ABSTRACT:

Introduction

Cortico-cortical evoked potentials (CCEPs) are utilized to identify effective networks in the human brain. Following single-pulse electrical stimulation of cortical electrodes, evoked responses are recorded from distant cortical areas. A negative deflection (N1) which occurs 10-50 ​ms post-stimulus is considered to be a marker for direct cortico-cortical connectivity. However, with CCEPs alone it is not possible to observe the white matter pathways that conduct the signal or accurately predict N1 amplitude and latency at downstream recoding sites. Here, we develop a new approach, termed "dynamic tractography," which integrates CCEP data with diffusion-weighted imaging (DWI) data collected from the same patients. This innovative method allows greater insights into corti

SUBMITTER: Silverstein BH 

PROVIDER: S-EPMC7292749 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature